Physical Biology of the Cell: A Review of the Book and Its Solutions
Physical Biology of the Cell is a textbook that aims to explore how the basic principles of physics and chemistry can explain the phenomena of life at the cellular level. The book covers topics such as molecular structures, thermodynamics, kinetics, electrostatics, mechanics, light, networks, patterns, and evolution. The book is written by Rob Phillips, Jane Kondev, Julie Theriot, and Hernan Garcia, who are experts in their respective fields of biophysics, biochemistry, cell biology, and computational biology.
The book is intended for advanced undergraduate and graduate students who have a background in calculus, physics, and chemistry. The book also provides a series of problems at the end of each chapter that challenge the readers to apply the concepts and methods learned in the text. The problems range from simple calculations to complex simulations and experiments. The book also offers hints to some of the problems on its website (http://www.rpgroup.caltech.edu/pboc2/).
However, some readers may find the problems too difficult or unclear without a complete solution manual. Fortunately, there are some online resources that provide solutions for some or all of the problems in the book. For example:
Numerade (https://www.numerade.com/books/physical-biology-of-the-cell-2nd/) offers video explanations for all of the problems in the second edition of the book.
Chegg (https://www.chegg.com/homework-help/physical-biology-of-the-cell-2nd-edition-solutions-9780429168833) offers step-by-step solutions for some of the problems in the second edition of the book.
The authors themselves provide hints to some of the problems on their website (http://www.rpgroup.caltech.edu/pboc2/assets/PBoC2_Problems_Hints02-08-13.pdf).
These resources can be helpful for students and instructors who use the book as a reference or a course material. However, they should not be used as a substitute for learning and understanding the concepts and methods presented in the book. The best way to master physical biology is to practice solving problems by oneself and compare one's solutions with others.In this article, we will briefly review some of the main topics covered in the book and highlight some of the key concepts and methods that are useful for physical biology.
Molecular Structures: Rulers at Many Different Scales
The first chapter of the book introduces the concept of biological structures and how they can be measured and visualized at different scales, from atoms to cells. The book emphasizes the importance of using appropriate units and dimensions when dealing with biological quantities and provides a table of common units and prefixes. The book also introduces the concept of scaling laws and how they can reveal the underlying principles that govern biological phenomena. For example, the book shows how the surface area to volume ratio affects the diffusion rate and metabolic rate of cells.
The book also introduces some of the tools and techniques that are used to study biological structures, such as microscopy, spectroscopy, X-ray crystallography, nuclear magnetic resonance (NMR), and molecular dynamics simulations. The book explains how these techniques can provide information about the size, shape, composition, and interactions of biological molecules and complexes. The book also provides some examples of how these techniques can be used to study specific biological systems, such as DNA, proteins, membranes, and cytoskeleton.
Mechanical and Chemical Equilibrium in the Living Cell
The second chapter of the book introduces the concept of equilibrium and how it applies to both mechanical and chemical systems in biology. The book explains how equilibrium can be defined in terms of forces or potentials and how it can be used to calculate the properties and behavior of biological systems. The book also explains how equilibrium can be disturbed by external factors or internal fluctuations and how biological systems can respond to these perturbations.
The book introduces some of the basic concepts and methods that are used to analyze mechanical and chemical equilibrium in biology, such as free energy, entropy, enthalpy, Gibbs free energy, chemical potential, osmotic pressure, Le Chatelier's principle, equilibrium constants, reaction rates, mass action law, and Michaelis-Menten kinetics. The book also provides some examples of how these concepts and methods can be used to study specific biological systems, such as protein folding, enzyme catalysis, membrane transport, cell signaling, and gene regulation. 061ffe29dd